منابع مشابه
Molecular basis of cold adaptation.
Cold-adapted, or psychrophilic, organisms are able to thrive at low temperatures in permanently cold environments, which in fact characterize the greatest proportion of our planet. Psychrophiles include both prokaryotic and eukaryotic organisms and thus represent a significant proportion of the living world. These organisms produce cold-evolved enzymes that are partially able to cope with the r...
متن کاملThe structural basis of molecular adaptation.
The study of molecular adaptation has long been fraught with difficulties, not the least of which is identifying out of hundreds of amino acid replacements those few directly responsible for major adaptations. Six studies are used to illustrate how phylogenies, site-directed mutagenesis, and a knowledge of protein structure combine to provide much deeper insights into the adaptive process than ...
متن کاملStructural basis for selectin mechanochemistry.
Selectins are adhesion molecules that resist large tensile forces applied by hydrodynamic forces to leukocytes binding to vessel walls. In crystals, the liganded (high-affinity) and unliganded (low-affinity) conformations differ in orientation between their tandem lectin and EGF domains. I examine how tensile force exerted on a selectin-ligand complex in vivo could favor the more extended, high...
متن کاملStructural Basis for Cooperative DNA
when the bacterial environment contains no lactose (Al-berts et al., 2002; Berg et al., 2002). The repressor functions as a dimer of two " hand " domains (Figure 1D). loop is critical for the lac operon repression (Matthews, 1992). The primary roles of CAP and LR are the opposite of Summary each other, yet the two proteins bind to DNA cooperatively (Hudson and Fried, 1990; Lewis et al., 1996). ...
متن کاملStructural basis for organohalide respiration.
Organohalide-respiring microorganisms can use a variety of persistent pollutants, including trichloroethene (TCE), as terminal electron acceptors. The final two-electron transfer step in organohalide respiration is catalyzed by reductive dehalogenases. Here we report the x-ray crystal structure of PceA, an archetypal dehalogenase from Sulfurospirillum multivorans, as well as structures of PceA ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.17.11761